Skip Navigation Skip to Content Skip to Footer

Mr Giacomo Mazzotti

I received my BSc degree at the University of Bologna, Italy. During my undergraduate studies, I focused on the synthesis of different peptides and their coupling to core-shell silica-PEG nanoparticles, for the targeting of αVβ3 integrins, over-expressed by several cancer cell lines. I then undertook a MSc at the University of Hawaii, USA, working on understanding the mechanism of α-carbon to sulfur crosslink formation, mediated by the radical S-adenosyl-L-methionine enzymes TrnC and TrnD, proteins involved in the post-translational modification of the bacteriocin thuricin CD, and on developing the in vivo production and purification of this natural product. I am now pursuing my DPhil in Chemical Biology at the University of Oxford, currently working on externally controllable small interfering RNAs.

Research Interests

Externally controllable nucleic acids.
My research group webpage:
My project funded by EPSCR:


De Marco, R., Mazzotti, G., Greco, A. & Gentilucci, L. Heterocyclic Scaffolds in the Design of Peptidomimetic Integrin Ligands: Synthesis Strategies, Structural Aspects, and Biological Activity. Curr. Opin. Med. Chem. 16, 3, 343-359 (2016).

De Marco, R. et al. 5-aminomethyloxazolidine-2,4-dione hybrid α/β-dipeptide scaffolds as inductors of constrained conformations: Applications to the synthesis of integrin antagonists. Biopolymers (Peptide Science) 104, 5, 636-649 (2015).