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Dr Brett William Clive Kennedy


Dr Brett Kennedy read Chemistry at the University of Bath and completed his PhD in cancer metabolism under Prof Kevin Brindle (FMedSci) at the University of Cambridge, using novel magnetic resonance techniques (13C Dissolution Dynamic Nuclear Polarisation). After a Post Doctoral appointment with Prof David Lurie in Aberdeen using Fast-Field-Cycling magnetic resonance to investigate changes to cartilage in osteoarthritis, Dr Kennedy read medicine at the University of Oxford on the accelerated 4-year graduate-entry program. He completed his Foundation training in Bristol as an Academic Foundation trainee and completed all parts of the MRCP as an FY2. He then took up an Academic Clinical Fellowship (ACF) in Cardiology in Thames Valley, where he remains as a Registrar in Cardiology. As part of his ACF, Dr Kennedy has recently completed a study with Prof Damien Tyler and Dr Kerstin Timm, examining the influence of SGLT2 inhibitors on heart function in pre-clinical models.

Research Interests

Dr Kennedy is interested in how the heart produces energy to sustain its function, and whether abnormal changes in this energy generation (metabolism) are responsible for some of the heart disease seen in patients. He is interested in whether targeting this abnormal metabolism can help the heart beat more efficiently, ultimately helping the many patients in the UK with heart disease.

Selected Publications

  • Hyperpolarised magnetic resonance spectroscopy of α-[1-13C]-ketoisocaproic acid reveals reamination of branched chain ketoacids
    BWC Kennedy, D Tyler, KN Timm
    Journal of Molecular and Cellular Cardiology 173, 187
  • Imaging tumor metabolism to assess disease progression and treatment response
    KN Timm, BWC Kennedy, KM Brindle
    Clinical Cancer Research 22 (21), 5196-5203
  • Probing Lactate Dehydrogenase Activity in Tumors by Measuring Hydrogen/Deuterium Exchange in Hyperpolarized l-[1-13C,U-2H]Lactate
    BWC Kennedy, MI Kettunen, DE Hu, KM Brindle
    Journal of the American Chemical Society 134 (10), 4969-4977
  • Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose
    TB Rodrigues, EM Serrao, BWC Kennedy, DE Hu, MI Kettunen, …
    Nature medicine 20 (1), 93-97