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Professor Sumana Sanyal

MA (MSc Indian Institute of Technology, PhD Cornell)

Professor Sanyal completed her PhD from Cornell University as part of the Cornell-Rockefeller-Sloan Kettering Tri-institutional program in Chemical Biology.

She did her post-doctoral training with Prof Hidde Ploegh at the Whitehead Institute for Biomedical Research of the Massachusetts Institute of Technology. Prior to joining Oxford, she was a Croucher Foundation sponsored Assistant Professor at the School of Public Health and School of Biomedical Sciences of the Faculty of Medicine at the University of Hong Kong.

Research Interests

Professor Sanyal’s research aims to better understand virus-host interactions, with a particular emphasis on flaviviruses such as Dengue and Zika. She uses functional proteomics to characterise host factors that are crucial for virus pathogenesis to gain insights not only into viral exploitation of cellular pathways and their strategies of evading host immunity, but also on fundamental host cell biology.

Selected Publications

Jahan AS, Biquand E, Munoz R, le Quang A, Mok C, Wong HH, Teo Q, Valkenburg SA, Chin A, Poon LLM, te Velthuis A, García-Sastre A, Demeret C and Sanyal S*. OTUB1 is a key regulator of RIG-I dependent immune signalling and is targeted for proteasomal degradation by influenza A NS1. (2020; Cell Reports. in press).

Wong HH and Sanyal S*. Manipulation of autophagy by (+) RNA viruses (2019) Semin Cell Dev Biol. S1084-9521 (18): 30222-2.

Zhang J, Lan Y, Li MY, Lamers MM, Fusade-Boyer M, Klemm E, Thiele C, Ashour J and Sanyal S*. Flaviviruses exploit the lipid droplet protein AUP1 to trigger lipophagy and drive virus production (2018) Cell Host Microbe. 23 (6): 819-831.

Zhang J, Lan Y and Sanyal S*. Modulation of lipid droplet metabolism – a potential target for therapeutic intervention in Flaviviridae infections. (2017) Front Microbiol. Nov 28; 8: 2286.

Jahan AS, Lestra M, Swee LK, Fan Y, Lamers MM, Tafesse FG, Theile CS, Spooner E, Bruzzone R, Ploegh HL and Sanyal S*. Usp12 stabilizes the T-cell receptor at the cell surface during signaling (2016) Proc Natl Acad Sci USA 113(6): E705-14.