After graduating with a BA (Hons) in Medical Sciences from Trinity College Oxford, I moved to London to complete a PhD in Cardiac Pharmacology at Imperial College under the supervision of Prof. Sian Harding and Dr Alex Lyon. I am now completing the clinical part of the BMBCh back in Oxford.
I continue to carry out research in Prof Sian Harding’s laboratory, focusing on the role of catecholamines in the induction of acute heart failure and the role of sex hormones in modulating the heart’s response to catecholamines.
Paur H, Wright PT, Sikkel MB, Tranter MH, Mansfield C, O’Gara P, Stuckey DJ, Nikolaev VO, Diakonov I, Pannell L, Gong H, Sun H, Peters NS, Petrou M, Zheng Z, Gorelik J, Lyon AR, Harding SE. High levels of circulating epinephrine trigger apical cardiodepression in a β2-adrenergic receptor/Gi-dependent manner: a new model of Takotsubo cardiomyopathy. Circulation. 2012;126:697–706.
Tranter MH, Wright PT, Sikkel MB, Lyon AR. Takotsubo cardiomyopathy: the pathophysiology. Heart Fail Clin. 2013;9:187–196.
Wright PT, Tranter MH, Morley-Smith AC, Lyon AR.Pathophysiology of Takotsubo Syndrome: temporal phases of cardiovascular responses to extreme stress. Circ J. 2014;78:1550-558.
Land S, Niederer SA, Louch WE, Røe ÅT, Aronsen JM, Stuckey DJ, Sikkel MB, Tranter MH, Lyon AR, Harding SE, Smith NP.Computational modeling of Takotsubo cardiomyopathy: effect of spatially varying β-adrenergic stimulation in the rat left ventricle. Am J Physiol Heart Circ Physiol. 2014 Nov 15;307(10):H1487-96.